Episode 27

Published on:

27th May 2022

Revving Up the CAR T: Fighting Fibrosis with Gene Therapy

CAR T cells have been engineered to treat everything from cancer to scarring in the heart. However, one major barrier to wide-spread therapy is the fact that T cells have to be removed from the patient, engineered, and then putting them back in the patient. But what if we could create a drug that makes CAR T cells inside a patient's own body? This type of one-size-fits-all approach could be much more efficient. On this episode of Beyond the Abstract, Derek and Dan discuss how scientists at the University of Pennsylvania have successfully created CAR T cells to treat scarring in the heart with the simple injection of a drug. Using state-of-the-art gene therapy, they are able to temporarily transform T cells into soldiers to fight scarring in the heart.

Rurik et al. CAR T cells produced in vivo to treat cardiac injury. Science, January 2022. DOI: 10.1126/science.abm0594

The information presented here is not medical advice. Consult your physician on any questions regarding your personal health.

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About the Podcast

Beyond the Abstract
Science and research for everyone
Hey science nerds! Welcome to Beyond the Abstract, a science podcast dedicated to discussion of the coolest cutting edge, basic science research papers in a way that just about anyone can understand. We're your hosts, Derek and Ellen, two MD/PhD students at the University of Pennsylvania who are passionate about science communication and bridging the gap between science and medicine.

In each episode, we’ll dive into a paper and talk about the experiments these scientists did, what it means for the future of research, and even potential impacts on human health and medicine. We've invited experts in these fields to help us understand and dissect these complicated but impactful papers.

We can't wait to share all this cool science with you.

Disclaimer: This podcast is for informational purposes only and NOT intended as medical advice. The views and opinions expressed are those of the hosts and guests and do not reflect the University of Pennsylvania.

Business contact: beyondabstractpod@gmail.com

About your hosts

Derek Sung, PhD

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Derek is a 6th year MD/PhD student at the University of Pennsylvania interested in developmental and vascular biology with plans to apply into Obstetrics & Gynecology. He received his PhD in Cell and Molecular Biology in 2022. He is the founder, co-developer, and co-host of Beyond the Abstract.

In his spare time, he likes to listen to All Star by Smash Mouth on repeat, smile too big for photos, pretend to be a sommelier, and throw epic Halloween parties with his roommate.

Ellen White

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Ellen is a 3rd year MD/PhD student at the University of Pennsylvania interested in microbiome research with the hopes of specializing in GI medicine. She is a co-developer and co-host of Beyond the Abstract. You can find her listening to Work by Rihanna (feat. Drake) on repeat, getting too invested in college basketball games, or shamelessly watching Real Housewives.

Dan Weiner

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Dan is a 4th year MD/PhD student at Harvard Medical School interested in genomics and neuropsychiatric disease research. He is co-host of Beyond the Abstract.

In his spare time you can find him watching every suggested YouTube video (mostly Colbert and cooking clips) and looking forward to watching the Red Sox at Fenway after the pandemic is over.