Episode 12

CRISPR: All About That Base (Editing)

CRISPR is a genome-editing technology that has revolutionized medical research and created new therapies for previously incurable diseases. But what is CRISPR exactly, where does it come from, and how does it work? In this episode of Beyond the Abstract, Ellen and Derek explore how scientists have created a method of using CRISPR to treat Sickle Cell Disease, a genetic disease of the blood that can be extremely painful. They also discuss how this therapy has impacted real patients beyond just the disease and talk about the importance of creating healthcare and treatments that are accessible to patients of all races and socioeconomic statuses.

Denver et al. CRISPR/Cas9 beta-globin gene targeting in human hematopoietic stem cells. Nature, November 2016. DOI: 10.1038/nature20134. PMID: 27820943.

The information presented here is not medical advice. Please follow all guidelines from the CDC in regards to social distancing. Consult your physician on any questions regarding your personal health.

About the Podcast

Show artwork for Beyond the Abstract
Beyond the Abstract
Science and research for everyone

About your hosts

Profile picture for Derek Sung

Derek Sung

Derek is a 4th year MD/PhD student at the University of Pennsylvania interested in developmental and vascular biology with plans to apply into Obstetrics & Gynecology. He is the founder, co-developer, and co-host of Beyond the Abstract.

In his spare time, he likes to listen to All Star by Smash Mouth on repeat, smile too big for photos, pretend to be a sommelier, and throw epic Halloween parties with his roommate.
Profile picture for Ellen White

Ellen White

Ellen is a 3rd year MD/PhD student at the University of Pennsylvania interested in microbiome research with the hopes of specializing in GI medicine. She is a co-developer and co-host of Beyond the Abstract. You can find her listening to Work by Rihanna (feat. Drake) on repeat, getting too invested in college basketball games, or shamelessly watching Real Housewives.