Episode 7

Published on:

4th Feb 2020

The Golden Phage

Alcoholic hepatitis is a severe, life-threatening type of liver disease, but not for all patients. Some patients seem to have worse outcomes than others, but what differentiates these patients and how do we treat them? In this episode, Derek and Ellen invite Sam McCright, an MD/PhD student at the University of Pennsylvania studying the microbiome, to talk about a new paper that discovers the potential bacterial culprit behind the most severe cases of alcoholic hepatitis. Even more, these scientists have found new ways to combat these bacteria. Instead of using antibiotics, they use phages, which are like little homing missiles that can target and destroy specific bacteria and are found in sewage. The secret to treating this disease just might literally be a load of crap.

Duan et al. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature, 2019. 575(7783):505-511. PMID: 31723265.

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About the Podcast

Beyond the Abstract
Science and research for everyone
Hey science nerds! Welcome to Beyond the Abstract, a science podcast dedicated to discussion of the coolest cutting edge, basic science research papers in a way that just about anyone can understand. We're your hosts, Derek and Ellen, two MD/PhD students at the University of Pennsylvania who are passionate about science communication and bridging the gap between science and medicine.

In each episode, we’ll dive into a paper and talk about the experiments these scientists did, what it means for the future of research, and even potential impacts on human health and medicine. We've invited experts in these fields to help us understand and dissect these complicated but impactful papers.

We can't wait to share all this cool science with you.

Disclaimer: This podcast is for informational purposes only and NOT intended as medical advice. The views and opinions expressed are those of the hosts and guests and do not reflect the University of Pennsylvania.

Business contact: beyondabstractpod@gmail.com

About your hosts

Ellen White

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Ellen is a 3rd year MD/PhD student at the University of Pennsylvania interested in microbiome research with the hopes of specializing in GI medicine. She is a co-developer and co-host of Beyond the Abstract. You can find her listening to Work by Rihanna (feat. Drake) on repeat, getting too invested in college basketball games, or shamelessly watching Real Housewives.

Derek Sung

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Derek is a 3rd year MD/PhD student at the University of Pennsylvania interested in developmental and vascular biology with plans to apply into Obstetrics & Gynecology. He is the founder, co-developer, and co-host of Beyond the Abstract.

In his spare time, he likes to listen to All Star by Smash Mouth on repeat, smile too big for photos, pretend to be a sommelier, and throw epic Halloween parties with his roommate.